The latest Windows 10 PC builds have been found to have issues running Windows Mobile Device Center (WMDC). WMDC may not work with the recently released Windows 10 version 1703, or any subsequent Windows 10 versions. This support note has recommendations and troubleshooting options to address WMDC connection issues resulting from incompatibility of WMDC and Windows 10.
A Registry editing tool for the PC OS is available to address the current known issue with Windows 10 version 1703 and can be downloaded from here. Instructions on how to use it are available in the Support Note below.